2010 South Florida Football Schedule
Tickets: College Football Tickets
| Date | Team | vs/at | Team | Location |
| Sep 4 | South Florida | vs | Stony Brook | Tampa |
| Sep 11 | South Florida | at | Florida | Gainesville |
| Sep 25 | South Florida | vs | Western Kentucky | Tampa |
| Oct 2 | South Florida | vs | Florida Atlantic | Tampa |
| Oct 9 | South Florida | vs | Syracuse | Tampa |
| Oct 14 | South Florida | at | West Virginia | Morgantown |
| Oct 22 | South Florida | at | Cincinnati | Cincinnati |
| Nov 3 | South Florida | vs | Rutgers | Tampa |
| Nov 13 | South Florida | at | Louisville | Louisville |
| Nov 20 | South Florida | vs | Pittsburgh | Tampa |
| Nov 27 | South Florida | at | Miami | Miami |
| Dec 4 | South Florida | vs | Connecticut | Tampa |
| 2009 College Football Bowl Schedule | ||||