2010 Michigan State Football Schedule
Tickets: College Football Tickets
| Date | Team | vs/at | Team | Location |
| Sep 4 | Michigan State | vs | Western Michigan | East Lansing |
| Sep 11 | Michigan State | vs | Florida Atlantic | Detroit |
| Sep 18 | Michigan State | vs | Notre Dame | East Lansing |
| Sep 25 | Michigan State | vs | Northern Colorado | East Lansing |
| Oct 2 | Michigan State | vs | Wisconsin | East Lansing |
| Oct 9 | Michigan State | at | Michigan | Ann Arbor |
| Oct 16 | Michigan State | vs | Illinois | East Lansing |
| Oct 23 | Michigan State | at | Northwestern | Evanston, IL |
| Oct 30 | Michigan State | at | Iowa | Iowa City |
| Nov 6 | Michigan State | vs | Minnesota | East Lansing |
| Nov 20 | Michigan State | vs | Purdue | East Lansing |
| Nov 27 | Michigan State | at | Penn State | University Park |
| 2009 College Football Bowl Schedule | ||||
