2010 Louisville Football Schedule
Tickets: College Football Tickets
| Date | Team | vs/at | Team | Location |
| Sep 4 | Louisville | vs | Kentucky | Louisville |
| Sep 11 | Louisville | vs | Eastern Kentucky | Louisville |
| Sep 18 | Louisville | at | Oregon State | Corvallis |
| Oct 2 | Louisville | at | Arkansas State | Jonesboro |
| Oct 9 | Louisville | vs | Memphis | Louisville |
| Oct 15 | Louisville | vs | Cincinnati | Louisville |
| Oct 23 | Louisville | vs | Connecticut | Louisville |
| Oct 30 | Louisville | at | Pittsburgh | Pittsburgh |
| Nov 6 | Louisville | at | Syracuse | Syracuse |
| Nov 13 | Louisville | vs | South Florida | Louisville |
| Nov 20 | Louisville | vs | West Virginia | Louisville |
| Nov 26 | Louisville | at | Rutgers | Piscataway, NJ |
| 2009 College Football Bowl Schedule | ||||