2010 Iowa State Football Schedule
Tickets: College Football Tickets
| Date | Team | vs/at | Team | Location |
| Sep 2 | Iowa State | vs | Northern Illinois | Ames |
| Sep 11 | Iowa State | at | Iowa | Iowa City |
| Sep 18 | Iowa State | at | Kansas State | Kansas City |
| Sep 25 | Iowa State | vs | Northern Iowa | Ames |
| Oct 2 | Iowa State | vs | Texas Tech | Ames |
| Oct 9 | Iowa State | vs | Utah | Ames |
| Oct 16 | Iowa State | at | Oklahoma | Norman |
| Oct 23 | Iowa State | at | Texas | Austin |
| Oct 30 | Iowa State | vs | Kansas | Ames |
| Nov 6 | Iowa State | vs | Nebraska | Ames |
| Nov 13 | Iowa State | at | Colorado | Boulder |
| Nov 20 | Iowa State | vs | Missouri | Ames |
| 2009 College Football Bowl Schedule | ||||
